2-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester
2-(Aminomethyl)-1-Boc-piperidine
CAS: 370069-31-1
Molecular Formula: C11H22N2O2
2-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester - Names and Identifiers
2-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C11H22N2O2 |
| Molar Mass | 214.3 |
| Density | 1.0124 g/mL at 25 °C |
| Boling Point | 299.4±13.0 °C(Predicted) |
| Flash Point | 110°C |
| Solubility | Soluble in DMSO |
| pKa | 10.32±0.29(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | n20/D 1.4745 |
| MDL | MFCD01317791 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
2-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R50 - Very Toxic to aquatic organisms |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3082 9/PG 3 |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
2-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester - Introduction
2-(Aminomethyl)-1-Boc-piperidine is an organic compound with the following properties:
-Appearance: White crystalline solid or colorless liquid
-Molecular formula: C13H24N2O2
-Molecular weight: 244.34g/mol
-Melting point: about 44-46 ℃
-Boiling point: about 228-230 ℃
-Solubility: Soluble in organic solvents such as dichloromethane, ethanol and dimethyl sulfoxide
2-(Aminomethyl)-1-Boc-piperidine is mainly used for protecting groups and catalysts in organic synthesis. Its most common use is as an activator in piperidine ring nucleophilic substitution reactions. In addition, it is useful as an intermediate and an amination reagent for piperidine dissociation derivatives.
The method for preparing 2-(Aminomethyl)-1-Boc-piperidine is usually obtained by reacting 2-aminomethylpiperidine with Boc-citric anhydride. The reaction is carried out under anhydrous and anaerobic conditions and requires sufficient base catalyst.
Regarding safety information, 2-(Aminomethyl)-1-Boc-piperidine is generally safe under normal operating conditions, but the following matters still need to be noted:
-contact with skin and eyes should be timely rinse clean
-Avoid inhaling aerosols or dust
-Avoid prolonged exposure and ingestion
-Use appropriate personal protective equipment, such as gloves and goggles, when operating
-Chemicals should be stored in a dry, dark and well-ventilated place
In general, 2-(Aminomethyl)-1-Boc-piperidine has a wide range of applications in organic synthesis, and it is safe when used and stored properly.
-Appearance: White crystalline solid or colorless liquid
-Molecular formula: C13H24N2O2
-Molecular weight: 244.34g/mol
-Melting point: about 44-46 ℃
-Boiling point: about 228-230 ℃
-Solubility: Soluble in organic solvents such as dichloromethane, ethanol and dimethyl sulfoxide
2-(Aminomethyl)-1-Boc-piperidine is mainly used for protecting groups and catalysts in organic synthesis. Its most common use is as an activator in piperidine ring nucleophilic substitution reactions. In addition, it is useful as an intermediate and an amination reagent for piperidine dissociation derivatives.
The method for preparing 2-(Aminomethyl)-1-Boc-piperidine is usually obtained by reacting 2-aminomethylpiperidine with Boc-citric anhydride. The reaction is carried out under anhydrous and anaerobic conditions and requires sufficient base catalyst.
Regarding safety information, 2-(Aminomethyl)-1-Boc-piperidine is generally safe under normal operating conditions, but the following matters still need to be noted:
-contact with skin and eyes should be timely rinse clean
-Avoid inhaling aerosols or dust
-Avoid prolonged exposure and ingestion
-Use appropriate personal protective equipment, such as gloves and goggles, when operating
-Chemicals should be stored in a dry, dark and well-ventilated place
In general, 2-(Aminomethyl)-1-Boc-piperidine has a wide range of applications in organic synthesis, and it is safe when used and stored properly.
Last Update：2024-04-10 22:29:15
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CAS: 370069-31-1
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QQ: 3008007409
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CAS: 370069-31-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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